EVOLUTION OF CG METHYLATION MAINTENANCE MACHINERY IN PLANTS
Cytosine methylation is an epigenetic mark present in most eukaryotic genomes that contributes to the regulation of gene expression and the maintenance of genome stability. DNA methylation mostly occurs at CG sequences, where it is initially deposited by de novo DNA methyltransferases and propagated by maintenance DNA methyltransferases (DNMT) during DNA replication. In this review, we first summarize the mechanisms maintaining CG methylation in mammals that involve the DNA Methyltransferase 1 (DNMT1) enzyme and its cofactor, UHRF1 (Ubiquitin-like with PHD and RING Finger domain 1). We then discuss the evolutionary conservation and diversification of these two core factors in the plant kingdom and speculate on potential functions of novel homologues typically observed in land plants but not in mammals.
OUR PAPER IS ONLINE IN THE PLANT JOURNAL
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MPS PHD STUDENTS RETREAT
Our lab Organised the 2019 CUSO PhD retreat in Brandboden
FIRST REVIEW FROM THE LAB
OUR PAPER HIGHLIGHTED IN PRELIGHTS
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